Publications
2024
Zeng, H., Mayberry, J.E., Wadkins, D., Chen, N., Summers, D.W., Kuehn, M.H. (2024) Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma. Acta Neuropathol Commun. 12(1):23 PubMed pdf
Zhang, X., Xi ,G., Feng, P., Li, C., Kuehn, M.H., Zhu, W. (2024) Intraocular pressure across the lifespan of Tg-MYOCY437H mice. Exp Eye Res.109855. Epub ahead of print PubMed¶
Wang, C.L; Skeie, J.M.; Allamargot, C.; Goldstein, A.S.; Nishimura, D.Y; Huffman, J.M.; Aldrich, B.T.; Schmidt, G.T.; Teixiera, L.B.C.; Kuehn, M.H.; Yorek, Y.; Greiner, M.A. (2024) Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye. Am J Pathol. 194(6):1090-1105 PubMed pdf¶
Fard, M.R.B, Chan, J. Read, A.T., Li, G., Cheng, L., Safa, B.N., Siadat, S.M., Jhunjhunwala, A., Grossniklaus, H.E., Emelianov, S.Y., Stamer, W.D., Kuehn, M.H., Ethier, C.R. (2024) Magnetically Steered Cell Therapy for Functional Restoration Of Intraocular Pressure Control In Open-Angle Glaucoma. bioRxiv PubMed
Acott, TS, Fautsch, MP, Mao, W, Ethier, CR, Huang, AS, Kelley, MJ, Aga, M, Bhattacharya, SK, Borras, T, Bovenkamp, D, Chowdhury, UR, Clark, AF, Dibas, MI, Du, Y, Elliott, MH, Faralli, JA, Gong, H, Herberg, S, Johnstone, MA, Kaufman, PL, Keller, KE, Kelly, RA, Krizaj, D, Kuehn, M.H., Li, HL, Lieberman, R, Lin, SC, Liu, Y, McDonnell, FS, McDowell, CM, McLellan, GJ, Mzyk, P, Nair, KS, Overby, DR, Peters, DM, Raghunathan, V, Rao, PV, Roddy, GW, Sharif, NA, Shim, MS, Sun, Y, Thomson, BR, Toris, CB, Willoughby, CE, Zhang, HF, Freddo, TF, Fuchshofer, R, Hill, KR, Karimi, A, Kizhatil, K, Kopcyznski, CC, Liton, P, Patel, G, Peng, M, Pattabiraman, PP, Prasanna, G, Reina-Torres, E, Samples, EG, Samples, JR, Steel, CL, Strohmaier, CA, Subramanian, P, Sugali, CK, van Batenburg-Sherwood, J, Wong, C, Youngblood, H, Zode, GS, White, E, Stamer, WD. (2024) Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Invest Ophthalmol Vis Sci. 65(14):32. PubMed
2023
Cheng, L., Kuehn, M.H. (2023) Human Retinal Organoids in Therapeutic Discovery: A Review of Applications. Handb Exp Pharmacol. 281:157-187 PubMed
Zhu, W., Zhang, X., Wu, S., Wang, N., Kuehn M.H. (2023) iPSCs-Based Therapy for Trabecular Meshwork. Handb Exp Pharmacol. 281:277-300 PubMed
Bahrani Fard, M.R., Chan, J., Sanchez Rodriguez, G., Yonk, M., Kuturu, S.R., Read, A.T., Emelianov, S.Y., Kuehn, M.H., Ethier, C.R. (2023) Improved magnetic delivery of cells to the trabecular meshwork in mice. Exp Eye Res. 234:109602 PubMed pdf
O'Driscoll, E., Hughes, E., Irnaten, M., Kuehn, M., Wallace, D., O'Brien, C. (2023) Role of Epithelial-to-Mesenchymal Transition of Retinal Pigment Epithelial Cells in Glaucoma Cupping. J Clin Med. 6;12(7):2737 PubMed
2022
Harper, M.M., Gramlich, O.W., Elwood, B., Boehme, N., Dutca, L.M, Kuehn, M.H. (2022) Immune responses in mice after blast-mediated traumatic brain injury TBI autonomously contribute to retinal ganglion cell dysfunction and death. Exp. Eye Res. 225:109272 PubMed pdf
Cheng, L., Cring, C.R., Wadkins, D.A., Kuehn, M.H. (2022) Absence of Connexin 43 Results in Smaller Retinas and Arrested Depolarized Retinal Progenitor Cells During Human Retinal Organoid Development. Stem Cells 40(6):592-604 PubMed pdf
Zeng, Z., Dumitrescu, A.V., Wadkins, D., Elwood, B.W., Gramlich, O.W., Kuehn, M.H. (2022) Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models. Biomolecules 12, 281 PubMed pdf
McDowell, C.M., Kizhatil, K., Elliott, M.H., Overby, D.R., van Batenburg-Sherwood, J., Millar, J.C., Kuehn, M.H., Zode, G., Acott, T.S., Anderson, M.G., Bhattacharya, S.K., Bertrand, J.A., Borras, T., Bovenkamp, D.E., Cheng, L., Danias, J., De Ieso, M.L., Du, Y., Faralli, J.A., Fuchshofer, R., Ganapathy, P.S., Gong, H., Herberg, S., Hernandez, H., Humphries, P., John, S.W.M., Kaufman, P.L., Keller, K.E., Kelley, M.J., Kelly, R.A., Krizaj, D., Kumar, A., Leonard, B.C., Lieberman, R.L., Liton, P., Liu, Y., Liu, K.C., Lopez, N.N., Mao, W., Mavlyutov, T., McDonnell, F., McLellan, G.J., Mzyk, P., Nartey, A., Pasquale, L.R., Patel, G.C., Pattabiraman, P.P., Peters, D.M., Raghunathan, V., Rao, P.V., Rayana, N., Raychaudhuri, U., Reina-Torres, E., Ren, R., Rhee, D., Chowdhury, U.R., Samples, J.R., Samples, E.G., Sharif, N., Schuman, J.S., Sheffield, V.C., Stevenson, C.H., Soundararajan, A., Subramanian, P., Sugali, C.K., Sun, Y., Toris, C.B., Torrejon, K.Y., Vahabikashi, A., Vranka, J.A., Wang, T., Willoughby, C.E., Xin, C., Yun, H., Zhang, H.F., Fautsch, M.P., Tamm, E.R., Clark, A.F., Ethier, C.R., Stamer, W.D. (2022) Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 63(2):12.PubMed pdf
Akurathi, A., Boese, E.A., Kardon, R.H., Ledolter, J., Kuehn, M.H., Harper, M.M. (2022) Decreased expression of glial-derived neurotrophic factor receptors in glaucomatous human retinas. Curr Eye Res. 47(4):597-605 PubMed pdf
2021
Sui, S., Yu, H., Wang, X., Wang, W., Yang, X., Pan, X., Zhou, Q., Xin, C., Du, R., Wu, S., Zhang, J., Cao, Q., Wang, N., Kuehn, M.H., Zhu, W. (2021) iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma. Invest Ophthalmol Vis Sci. 62(10):28. PubMed pdf
Shestopalov, V.I., Spurlock, M., Gramlich, O.W., Kuehn, M.H. (2021) Immune Responses in the Glaucomatous Retina: Regulation and Dynamics. Cells. 10(8), 1973 PubMed pdf
Gramlich, O.W., Godwin, C.R., Wadkins, D., Elwood, B.W., Kuehn, M.H. (2021) Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation Int. J. Molec. Sci. 22, 7581 PubMed pdf
Wang, W., Miao, Y., Sui, S., Wang, Y., Wu, S., Cao, Q., Duan, H., Qi, X., Zhou, Q., Pan, X., Zhang, J., Chen, X., Han, Y., Wang, N., Kuehn, M.H., Zhu, W. (2021) Xeno- and Feeder-Free Differentiation of Human iPSCs to Trabecular Meshwork-Like Cells by Recombinant Cytokines. Transl. Vis. Sci. Technol. 3;10(6):27 PubMed pdf
Becker, K., Klein, H., Simon, E., Viollet, C, Haslinger, C., Leparc, G., Schultheis, C., Chong, V., Kuehn, M.H., Fernandez-Albert, F., Bakker, R.A. (2021) In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy. Sci. Rep. 11(1):10494 PubMed pdf
Kuehn, M.H., Vranka, J.A., Wadkins, D., Jackson, T., Cheng, L., Ledolter, J. (2021) Circumferential trabecular meshwork cell density in the human eye. Exp Eye Res. 205:108494 PubMed pdf
2020
Gramlich, O.W., Godwin, C.R., Heuss, N.D., Gregerson, D.S., Kuehn, M.H. (2020) T and B lymphocyte deficiency in Rag1-/- mice reduces retinal ganglion cell loss in experimental glaucoma. Invest Ophthalmol Vis Sci 61(14):18 PubMed pdf
Grozdanic, S.D., Lazic, T., Kecova H., Mohan, K., Kuehn, M.H. (2020) Presumed Cancer-Associated Retinopathy (CAR) mimicking Sudden Acquired Retinal Degeneration Syndrome (SARDS) in canines Vet Ophthalmol 24(2):125-155 PubMed pdf
Harper, M.M., Boese, E.A., Kardon, R.H., Ledolter, J., Kuehn, M.H. (2020) High Correlation between Glaucoma Treatment with Topical Prostaglandin Analogs and BDNF Immunoreactivity in Human Retina. Curr. Eye Res. 27:1-7 PubMed
Cheng, L., Zhu, W., Wareham, L.K., Buys, E., Kuehn, M.H. (2020) Trabecular meshwork restoration in primary open-angle glaucoma using stem cells. In: J. R. Samples and P. Knepper (Eds.), Glaucoma Research 2020-2022, Kugler Publications, Amsterdam, 2020, pp. 29-40. pdf
Zhu, W., Godwin, C.R., Cheng, L., Scheetz, T.E., Kuehn, M.H. (2020) Transplantation of iPSC-TM stimulates division of trabecular meshwork cells in human eyes. Sci. Rep. 10:2905 PubMed pdf
2019
Harper, M.M, Hedberg-Buenz, A., Herlein, J., Abrahamson, E.E., Anderson, M.G., Kuehn, M.H., Kardon, R.H., Poolman, P, Ikonomovic, M.D. (2019) Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci. 60(7):2716-2725 PubMed pdf
Oliver, J.A.C., Ricketts, S.L., Kuehn, M.H., Mellersh, C.S. (2019) Primary closed angle glaucoma in the Basset Hound: Genetic Investigations using genome wide association and RNA-sequencing strategies Mol. Vis. 25:93-105 PubMed pdf
Grozdanic, S., Lazic, T., Kecova, H. Mohan, K., Kuehn, M.H. (2019) Optical coherence tomography and molecular analysis of sudden acquired retinal degeneration syndrome (SARDS) eyes suggests the immune-mediated nature of retinal damage. Vet. Ophthalmology 22(3):305-327 PubMed pdf
Kuehn, M.H., Mishra, R., Deonovic, B.E., Miller, K.N., McCormack, S.E., Liu, G.T., Kupersmith, M.J., Wall, M., and the NORDIC IIHTT Study Group (2019) Genetic Survey of Adult Onset Idiopathic Intracranial Hypertension J. Neuro Ophthalmol. 39(1):50-55 PubMed pdf Supplemental Materials
2018
van der Heide, C.J., Alward, W.L.M., Flamme-Wiese, M., Riker, M., Syed, N., Carter, K., Kuehn, M.H., Mullins, R.F., Fingert, J.H. (2018) Histochemical analysis of glaucoma caused by a MYOC mutation in a human donor eye. Ophthalmology Glaucoma 1(2):132–138 pdf
Keller, K.E., Bhattacharya, S.K., Borras, T., Brunner, T.M., Chansangpetch, S., Clark, A.F., Dismuke, W.M., Du, Y., Elliott ,M.H., Ethier, C.R., Faralli, J.A,. Freddo, T.F., Fuchshofer, R., Giovingo, M., Gong, H., Gonzalez, P., Huang, A., Johnstone, M.A., Kaufman, P.L., Kelley, M.J., Knepper, P.A., Kopczynski, C.C., Kuchtey, J.G., Kuchtey, R.W., Kuehn, M.H., Lieberman, R.L., Lin, S.C., Liton, P., Liu, Y., Lütjen-Drecoll, E., Mao, W., Masis-Solano, M., McDonnell, F., McDowell, C.M., Overby, D.R., Pattabiraman, P.P., Raghunathan, V.K., Rao, P.V., Rhee, D.J., Chowdhury, U.R., Russell, P., Samples, J.R., Schwartz, D., Stubbs, E.B., Tamm, E.R., Tan, J.C., Toris, C.B., Torrejon, K.Y., Vranka, J.A., Wirtz, M.K., Yorio, T., Zhang, J., Zode, G.S., Fautsch, M.P., Peters, D.M., Acott, T.S., Stamer, W.D. (2018) Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res. 171:164-173 PubMed
2017
Zhu, W., Jain, A., Gramlich, O.W., Tucker, B.A., Sheffield, V.C., Kuehn, M.H. (2017) Restoration of Aqueous Humor Outflow following Transplantation of iPSC-derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma. Invest Ophthalmol Vis Sci. 58(4):2054-2062. PubMed pdf
Muenster, S., Lieb, W.S., Fabry, G., Allen, K.N., Kamat, S.S., Guy, A.H., Dordea, A.C., Teixeira, L., Tainsh, R.E., Yu, B., Zhu, W., Ashpole, N.E., Malhotra, R., Brouckaert, P., Bloch, D.B., Scherrer-Crosbie, M., Stamer, W.D., Kuehn, M.H., Pasquale, L,R., Buys, E.S. (2017) The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase. Invest Ophthalmol Vis Sci. 58(11):4826-4835 PubMed pdf
Williams, P.A., Marsh-Armstrong, N., Howell, G.R., Bosco, A., Danias, J., Simon. J., Di Polo, A., Kuehn, M.H., Przedborski, S., Raff, M., Trounce, I. (2017) Neuroinflammation in glaucoma: A new opportunity. Exp Eye Res. 157:20-27. PubMed
2016
Chirco, K.R., Hazlewood, R.J., Miller, K., Workalemahu, G., Jampol, L.M., Lesser, G.R., Mullins, R.F., Kuehn, M.H., Fingert, J.H. (2016) MMP19 expression in the human optic nerve. Mol. Vis. 22:1429-1436 PubMed pdf
Lavik, E.B., Kuehn, M.H., Shoffstall, A., Atkins, K., Dumitrescu, A.V., Kwon, Y.H. (2016) Sustained Delivery of Timolol Maleate for over 90 days via Subconjunctival Injection. J. Ocul. Pharmacol. Ther. 32(10):642-649 PubMed
Zhu, W, Gramlich, O.W., Laboissonniere, L., Jain, A., Sheffield, V.C., Trimarchi, J.M., Tucker, B.A., Kuehn, M.H. (2016) Transplantation of iPSC-derived trabecular meshwork cells rescues glaucoma phenotypes in a mouse model of disease. Proc. Nat. Acad. Sci USA. 113(25):E3492-500 PubMed pdf
Gramlich, O.W., Burand, A.J., Brown, A.J., Deutsch, R.J., Kuehn, M.H., Ankrum, J.A. (2016) Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury model: Toward an off-the-shelf Therapy. Sci. Rep. 6:26463 PubMed pdf
Kuehn, M.H., Lipsett, K.A., Menotti-Raymond, M., Whitmore, S.S., Scheetz, T.E. David, V.A., O'Brien, S.J., Zhao, Z., Jens, J.K., Snella, E.A., Ellinwood, N.W., McLellan, G.J. (2016) A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus). PLoS One 5;11(5):e0154412 PubMed pdf
Sohn, E.H, van Dijk, H.W., Jiao, C., Kok, PHB, Jeong, W., Demarkaya, N., Garmager, A., Wit, F., Kucukevcilioglu, M., van Velthoven, M.E.J., DeVries, H., Mullins, R.F., Kuehn, M.H., Schlingemann, R.O., Sonka, M., Verbraak, F.D., Abramoff, M.D. (2016) Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc. Nat. Acad. Sci USA 113(19):E2655-64 PubMed
2015
Gramlich, O.W., Ding, Q.J., Zhu, W., Cook, A., Anderson, M.G., Kuehn, M.H. (2015) Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients. Acta Neuropathol. Commun. 3:56 PubMed pdf
Yang, X., Hondur, G., Li, M., Cai, J., Klein, J.B., Kuehn, M.H., Tezel, G. (2015) Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina. Invest Ophthalmol Vis Sci. 56(10):5816-5830 PubMed pdf
Ahram, D.F., Alward, W.L., Kuehn M.H. (2015) The Genetic Mechanisms of Primary Angle Closure Glaucoma Eye 29(10): 1251–1259 PubMed pdf
Ahram, D.F., Grozdanic, S.D., Kecova, H., Henkes, A., Collin, R.W., Kuehn, M.H. (2015) Variants in Nebulin (NEB) Are Linked to the Development of Familial Primary Angle Closure Glaucoma in Basset Hounds. PLoS One 4;10(5):e0126660 PubMed pdf
Hazlewood, R.J., Roos, B.R., Solivan-Timpe, F., Honkanen, R.A., Jampol, L.M., Gieser, S.C., Meyer, K.J., Mullins, R.F., Kuehn, M.H., Scheetz, T.E., Kwon, Y.H., Alward, W.L., Stone, E.M., Fingert, J.H. (2015) Heterozygous Triplication of Upstream Regulatory Sequences Leads to Dysregulation of Matrix Metalloproteinase 19 (MMP19) in Patients with Cavitary Optic Disc Anomaly (CODA). Hum Mutat. 36(3):369-78 PubMed
2014
Ding Q.J., Zhu W., Cook A.C., Anfinson K.R., Tucker B.A., Kuehn M.H. (2014) Induction of Trabecular Meshwork Cells from Induced Pluripotent Stem Cells. Invest Ophthalmol Vis Sci. 55:7065-72 PubMed pdf
Kuehn, M.H. (2014) Immune Phenomena in Glaucoma and Conformational Disorders: Why is the Second Eye Not Involved? J. Glaucoma S59-61 PubMed pdf
Ahram, D., Kecova, H., Cook, A.C., Grozdanic, S.D., Kuehn, M.H. (2014) Identification of Genetic Loci Associated with Primary Angle Closure Glaucoma in the Basset Hound. Mol. Vis. 20:497-510 PubMed pdf
2013
Fernandez de Castro, J.P., Mullins, R.F., Manea, A.M., Hernandez, J., Wallen, T.J., Kuehn, M.H. (2013) Lipofuscin in Human Glaucomatous Optic Nerves. Exp. Eye Res. 111:61-6 PubMed pdf
Scheetz, T.E., Fingert, J.H., Wang, K., Kuehn, M.H., Knudtson, K.L., Alward, W.L.M., Boldt, H.C., Russell, S.R., Folk, J.C., Casavant, T.L., Braun, T.A., Clark, A.F., Edwin M. Stone, E.M., Sheffield, V.C. (2013) A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel loci. PLoS One 2013;8(3):e58657 PubMed pdf
2012
Ding, Q.J., Cook, A.C, Dumitrescu, A.V., Kuehn, M.H. (2012) Lack of immunoglobulins does not prevent C1q binding to RGC and does not alter the progression of experimental glaucoma. Invest. Ophthalmol Vis. Sci. 53(10):6370-77 PubMed pdf
Mullins, R.F., Kuehn, M.H., Radu, R.A., Enriquez, G.S., East, J.S., Schindler, E.I., Travis, G.H., Stone, E.M. (2012) Autosomal Recessive Retinitis Pigmentosa Due To Abca4 Mutations: Clinical, Pathologic And Molecular Characterization Invest. Ophthalmol Vis. Sci. 53(4):1883-94 PubMed
2011
Yang, X., Luo, C., Cai, J., Powell, D., Yu, D., Kuehn, M.H., Tezel, G. (2011) Neurodegenerative and Inflammatory Pathway Components linked to TNF-α/TNFR1 Signaling in the Glaucomatous Human Retina. Invest. Ophthalmol Vis. Sci. 52(11):8442-54 PubMed
Zode, G.S., Kuehn, M.H., Nishimura, D.Y., Searby, C.C., Mohan, K., Grozdanic, S.D., Bugge, K., Anderson, M.G., Clark, A.F., Stone, E.M., Sheffield, V.C.(2011) Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma J. Clinical Invest. 121(9):3542-53 PubMed
Sigle, K.J., Camaño-Garcia, G., Carriquiry, A.L., Betts, D.M., Kuehn, M.H., McLellan, G.J. (2011) The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma. Vet. Ophthalmol. 1:48-53 PubMed
Kuehn, M.H, Wang, K., Roos, B., Stone, E.M., Kwon, Y.H. Alward, W.L.M. Mullins, R.F., Fingert, J.H. (2011) Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort. Mol. Vis. 17:430-435 PubMed pdf
Mullins, R.F., Dewald, A.D., Streb, L.M., Wang, K., Kuehn, M.H., Stone, E.M. (2011) Elevated membrane attack complex in human choroid with high risk complement factor H genotypes. Exp. Eye Res. 93(4):565-7 PubMed
Rutz-Mendicino, M.M., Snella, E.M., Jens, J.K., Gandolfi, B., Carlson, S.A., Kuehn, M.H., McLellan, G.J., Ellinwood, N.M. (2011) Removal of potentially confounding phenotypes from a siamese-derived feline glaucoma breeding colony. Comp Med. 61(3):251-7.PubMed
Harper, M.M., Grozdanic, S.D., Blits, B., Kuehn, M.H., Zamzow, D., Buss, J.E., Kardon, R.H., Sakaguchi, D.S. (2011) Transplantation of BDNF secreting mesenchymal stem cells provides neuroprotection in chronic hypertensive rat eyes. Invest. Ophthalmol Vis Sci. 52(7):4506-15 PubMed
Lavik, E., Kuehn, M.H., Kwon, Y.H. (2011) Novel drug delivery systems for glaucoma. Eye 25(5):578-86 PubMed
Trantow, C.M., Cuffy, T.L., Fingert, J.H., Kuehn, M.H., Anderson, M.G. (2011) Microarray analysis of iris gene expression in mice with mutations influencing pigmentation. Invest. Ophthalmol Vis Sci. 52(1):237-48 PubMed pdf
2010
Jiang, B., Harper, M.M., Kecova, H., Adamus, G., Kardon, R.H., Grozdanic, S.G., Kuehn. M.H. (2010) Neuroinflammation in Advanced Canine Glaucoma. Mol. Vis. 16:2092-108 PubMed pdf
Luo, C., Yang. X, Kain, A., Powell, D., Kuehn, M.H., Tezel, G. (2010) Glaucomatous Tissue Stress and the Regulation of Immune Response Through the Glial Toll-like Receptor Signaling. Invest. Ophthalmol Vis. Sci. 51(11):5697-707 PubMed pdf
Tezel, G., Yang, X., Luo, C., Kain, A., Powell, D., Kuehn, M.H., Kaplan, H.J. (2010) Oxidative Stress and the Regulation of Complement Activation in Human Glaucoma. Invest. Ophthalmol Vis. Sci. 51(10):5071-82 PubMed pdf
Grozdanic, S.D., Lazic, T., Kuehn, M.H., Harper, M.M, Kardon, R.H, Kwon, Y.H., Lavik, E.B., Sakaguchi, D.S. (2010) Exogenous modulation of intrinsic optic nerve neuroprotective activity. Graefes Arch Clin Exp Ophthalmol. 248(8):1105-16 PubMed pdf
Tezel, G., Yang, X., Luo, C, Cai, J., Kain, A.D., Powell, D.W., Kuehn, M.H., Pierce, W.M. (2010) Hemoglobin Expression and Regulation in Glaucoma: Insights into Retinal Ganglion Cell Oxygenation. Invest. Ophth. Vis. Sci. 51:907-919 PubMed pdf
Grozdanic, S.D., Kecova, H., Harper M.M., Nilaweera, W.U., Kuehn, M.H., Kardon, R.H. (2010) Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Invest. Ophth. Vis. Sci. 51:255-263 PubMed pdf
Lively, G.D., Jiang, B., Hedberg-Buenz, A., Chang, B., Petersen, G.E., Wang, K., Kuehn, M.H., Anderson, M.G. (2010) Genetic Dependence of Central Corneal Thickness among Inbred Strains of Mice. Invest. Ophthalmol Vis. Sci. 51:160–171 PubMed pdf
2009
Kwon, Y.H., Fingert, J.H., Kuehn, M.H., Alward, W.L.M. (2009) Mechanism of Disease: Primary Open Angle Glaucoma. N. Engl. J. Med. 360(11): 1113-1124 PubMed pdf
Tezel, G., and the Fourth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group (2009) The role of glia, mitochondria, and the immune system in glaucoma. Invest. Ophthalmol Vis. Sci. 50(3):1001-12 PubMed pdf
2008
Kuehn, M.H., Kim, C.Y., Jiang, B, Dumitrescu, A.V., Kwon, Y.H. (2008) Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Exp. Eye Res. 87: 89-95 PubMed pdf
Ostojic, J., Grozdanic, S.D., Syed, N.A., Hargrove M.S., Trent III J.T., Kuehn M.H., Kwon Y.H., Kardon R.H., and Sakaguchi D.S. (2008) Patterns of Distribution of the Oxygen-Binding Globins, Neuroglobin and Cytoglobin, in Human Retina. Arch. Ophthalmol. 126(11):1530-6 PubMed
Ostojic, J., Grozdanic, S.D., Syed, N.A., Hargrove M.S., Trent III J.T., Kuehn M.H., Kwon Y.H., Kardon R.H., and Sakaguchi D.S. (2008) Neuroglobin and Cytoglobin Distribution in the Anterior Eye Segment: a Comparative Immunohistochemical Study. J. Histochem. Cytochem. 56:863-872 PubMed
2007
Mullins, R.F, Kuehn, M.H., Faidley, E.A., Syed, N.A., Stone, E.M. (2007) Differential Macular and Peripheral Expression of Bestrophin in Human Eyes and its Implication for Best Disease. Invest Ophthalmol Vis Sci. 48:3372-3380 PubMed
2006
Kim, C.Y., Kuehn, M.H., Clark, A.F., and Kwon, Y.H. (2006) Gene Expression Profile of the Adult Human Retinal Ganglion Cell Layer. Mol. Vision 12: 1640-8 PubMed pdf
Kim, C.Y., Kuehn, M.H., Anderson, M.G., and Kwon, Y.H. (2006) Intraocular Pressure Measurement in Mice: A Comparison between Goldmann and Rebound Tonometry. Eye 20: 1-8 PubMed
Kuehn, M.H, Kim, C.Y., Ostojic, J, Bellin, M, Alward, W.L.M, Stone, E.M., Sakaguchi, D.S., Grozdanic, S.D. Kwon, Y.H. (2006) Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp. Eye Res. 83 (3):620-8 PubMed pdf
Mullins, R.F, Skeie, J.M., Malone, E.A, and Kuehn, M.H. (2006) Macular and Peripheral Distribution of ICAM-1 in the Human Choriocapillaris and Retina. Mol. Vis. 12: 224-25 PubMed pdf
Ostojic J., Sakaguchi D. S., de Lathouder Y., Hargrove M. S., Trent III J. T., Kwon Y.H., Kardon R. H., Kuehn M. H., Betts D. M., and Grozdanic S. D., (2006). Neuroglobin and Cytoglobin: Oxygen-Binding Proteins in Retinal Neurons. Invest Ophthalmol Vis Sci 47(3): 1016-23 PubMed
2005
Kuehn, M.H., Fingert, J.H., and Kwon, Y.H. (2005) Retinal Ganglion Cell Death in Glaucoma: Mechanisms and Neuroprotective Strategies. Ophthalmol Clin North Am. 18, 383-395 PubMed pdf
2004
Stone, E.M, Braun, T.A., Russell, S.R, Kuehn, M.H., Lotery, A.J., Moore, P.A, Christopher G. Eastman, C.G, Casavant, T.C., and Sheffield, V.C. (2004) Missense Variations in the Fibulin 5 Gene and age-related macular degeneration. N. Engl. J. Med. 351(4): 346-53. PubMed
2001
Kuehn, M.H., Stone, E.S., and Hageman, G.S. (2001) Organization of the Human IPM 200 Gene (IMPG2) and its Evaluation as a Candidate Gene in Age-related Macular Degeneration, Retinitis Pigmentosa and Leber Congenital Amaurosis. Invest. Ophthalmol. Vis. Sci. 13:3123-3129 PubMed
Alagramam, K.N., Yuan, H., Kuehn, M.H. et al. (2001) Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum. Mol. Genet. 10:1709-18. PubMed
Ruiz, A., Kuehn, M.H., Stone, E.S., Hageman, G.S., and Bok, D. (2001) Characterization of the lecithin retinol acyltransferase (LRAT) gene structure and evaluation of it’s involvement in ocular disease. Invest. Ophthalmol. Vis. Sci. 1:31-37 PubMed
2000
Kuehn, M.H., Wietecki, D. T., and Hageman, G. S. (2000) Molecular characterization of the murine orthologue of the human retinal proteoglycan IPM 150, Mol. Vis. 6:148-156. PubMed pdf
1999
Kuehn, M.H. and Hageman, G.S. (1999) Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan. Matrix Biology 18:509-518 PubMed pdf
Kuehn, M.H. and Hageman, G.S. (1999) Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans. Molec. Cell. Biol. Res. Commun 2:103-110 PubMed pdf
Gorin, M.B., Breitner, J. C. S., De Jong, P. T. V. M., Hageman, G. S., Klaver, C. C. W., Kuehn, M. H. and Seddon, J. M. (1999) The genetics of age-related macular degeneration. Mol. Vis. 5:29 PubMed pdf
Hageman, G.S., and Kuehn, M.H. (1998) Biology of the retina-IPM-RPE interface, in The Pigmented Retinal Epithelium: Current Aspects of Function and Disease., Marmor, M., and Wolfensberger, T., Eds., Oxford University Press, New York, pp. 417-454
